The District of South Carolina will observe the following legal public holidays in calendar year 2025.
| Holiday | Day | Observed |
| New Year's Day | Wednesday | January 1 |
| Martin Luther King, Jr's Birthday | Monday | January 20 |
| Washington's Birthday | Monday | February 17 |
| Memorial Day | Monday | May 26 |
| Juneteenth National Independence Day | Thursday | June 19 |
| Independence Day | Friday | July 4 |
| Labor Day | Monday | September 1 |
| Columbus Day | Monday | October13 |
| Veterans Day | Tuesday | November 11 |
| Thanksgiving Day | Thursday | November 27 |
| Christmas Day | Thursday | December 25 |
* Holiday observed