The District of South Carolina will observe the following legal public holidays in calendar year 2021.
| Holiday | Day | Observed |
| New Year's Day | Friday | January 1 |
| Martin Luther King, Jr's Birthday | Monday | January 18 |
| Washington's Birthday | Monday | February 15 |
| Memorial Day | Monday | May 31 |
| Juneteenth National Independence Day | Friday | June 18 |
| Independence Day | Monday | July 5 |
| Labor Day | Monday | September 6 |
| Columbus Day | Monday | October 11 |
| Veterans Day | Thursday | November 11 |
| Thanksgiving Day | Thursday | November 25 |
| Christmas Day | Friday | December 24* |
* Holiday observed